ChloroquineV1, Main, Exploration, bibRecord, 001462

The antimalarial ferroquine: from bench to clinic.

Identifieur interne : 001462 ( Main/Exploration ); précédent : 001461; suivant : 001463

The antimalarial ferroquine: from bench to clinic.

Auteurs : Christophe Biot [France] ; F. Nosten [Royaume-Uni] ; L. Fraisse [France] ; D. Ter-Minassian [France] ; Jamal Khalife [France] ; Daniel Dive [France]

Source :

Parasite [ 1252-607X ] ; 2011.

RBID : Hal:hal-00642112

Descripteurs français

mix :
- bio-organométallique, candidat médicament, ferroquine, mécanisme d’action, paludisme, résistance.

English descriptors

mix :
- bioorganometallics, drug candidate, ferroquine, malaria, mechanism of action, resistance.

Abstract

Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.

Url:

https://hal.archives-ouvertes.fr/hal-00642112

DOI: 10.1051/parasite/2011183207

Affiliations:

France, Royaume-Uni

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000237
to stream Hal, to step Curation: 000237
to stream Hal, to step Checkpoint: 000170
to stream Main, to step Merge: 001464
to stream Main, to step Curation: 001462

Le document en format XML

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              <country key="FR"></country>
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        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
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<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1019" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
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          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
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          </desc>
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</tutelle>
<tutelle name="IFR142" active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
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</tutelle>
<tutelle name="UMR8204" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
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          </desc>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106189" status="VALID">          <idno type="IdRef">190712678</idno>
          <idno type="ISNI">0000 0004 0386 3856</idno>
          <idno type="RNSR">201019101Y</idno>
          <orgName>Centre d’Infection et d’Immunité de Lille (CIIL) - U1019 - UMR 8204</orgName>
          <orgName type="acronym">CIIL</orgName>
          <date type="start">2010-01-01</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019 - BP 245</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ciil.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300166" type="direct"></relation>
            <relation active="#struct-301247" type="indirect"></relation>
            <relation name="U1019" active="#struct-303623" type="direct"></relation>
            <relation name="IFR142" active="#struct-374570" type="direct"></relation>
            <relation name="UMR8204" active="#struct-441569" type="direct"></relation>
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        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1019" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="IFR142" active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8204" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1051/parasite/2011183207</idno>
<series><title level="j">Parasite</title>
<idno type="ISSN">1252-607X</idno>
<imprint><date type="datePub">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>bioorganometallics</term>
<term>drug candidate</term>
<term>ferroquine</term>
<term>malaria</term>
<term>mechanism of action</term>
<term>resistance</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>bio-organométallique</term>
<term>candidat médicament</term>
<term>ferroquine</term>
<term>mécanisme d’action</term>
<term>paludisme</term>
<term>résistance</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
</noRegion>
<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Fraisse, L" sort="Fraisse, L" uniqKey="Fraisse L" first="L." last="Fraisse">L. Fraisse</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<name sortKey="Ter Minassian, D" sort="Ter Minassian, D" uniqKey="Ter Minassian D" first="D." last="Ter-Minassian">D. Ter-Minassian</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Nosten, F" sort="Nosten, F" uniqKey="Nosten F" first="F." last="Nosten">F. Nosten</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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The antimalarial ferroquine: from bench to clinic.

The antimalarial ferroquine: from bench to clinic.

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